Telmisartan and Amlodipine Uses
Telmisartan and Amlodipine Uses, Telmisartan is a medicine that is used to treat high blood pressure. It works by reducing the levels of angiotensin II (ANG II) in the body.
It is a popular antihypertensive drug that has been prescribed to millions of people worldwide. However, it can cause side effects.[1]
What is amlodipine and telmisartan?
Amlodipine and telmisartan are medications used to treat high blood pressure (hypertension). They also reduce the chances of a heart attack or stroke. They work by relaxing the blood vessels, which increases blood flow.
They are also used to reduce fluid retention, which can be caused by many medical conditions. They can be taken by mouth or in a liquid form. They also decrease the risk of kidney problems.
The two drugs can also be used together to control high blood pressure and prevent heart attacks. They also increase the effectiveness of other medicines that are used to treat this condition.[2]
This combination is more effective at lowering blood pressure than taking each drug separately. It may also be easier to take than other antihypertensive medicines.
It is also more effective in patients with certain medical conditions, such as congestive heart failure. It can also be used to treat diabetes.
Amlodipine is a calcium channel blocker that relaxes the blood vessels and lowers blood pressure. It is also used to treat edoema or fluid retention.
Telmisartan is an angiotensin receptor blocker that can reduce blood pressure. It is also a diuretic that can remove excess water and electrolytes from the body.
Warnings
Aside from its blood pressure lowering effects, telmisartan and amlodipine also comes with a host of side effects to boot. These include nausea, vomiting, and dizziness. The medicine may also cause a minor side effect known as hypokalemia (low potassium) which can be dangerous if not treated promptly and properly. In short, telmisartan and amlodipine is best used under close supervision and in conjunction with other medications. This is especially true for the hypertension drugs, wherein combining telmisartan and amlodipine with diuretics can lead to dangerously low potassium levels. The above mentioned side effects are a major concern in a high blood pressure patient with comorbid kidney disease or other serious medical conditions.[3]
Before taking this medicine
Amlodipine and telmisartan are used for the treatment of high blood pressure. They are used to reduce blood pressure and improve circulation, which helps prevent strokes and heart attacks. They are also helpful in preventing other cardiovascular problems.
They are also used to treat edema (fluid retention) in people with kidney disease or a condition that causes swelling. They work by relaxing the blood vessels and reducing blood pressure over time.
They are taken by mouth, usually in the morning. They should be taken at the same time each day, unless your doctor tells you to take them later in the day. They can cause stomach problems, so drink plenty of water while taking them. If you are having problems, talk to your doctor.[4]
How should I take amlodipine and telmisartan?
If you are taking this medicine for the treatment of high blood pressure, you should take it at the same time every day. It is important to continue taking the medicine even if you don’t feel well. This will help you get the best results from it.
Amlodipine is a calcium channel blocker that works by relaxing the blood vessels. Telmisartan is an angiotensin receptor blocker (ARB) that reduces blood pressure by blocking the action of a chemical called angiotensin II. The combination of these two medicines helps lower your blood pressure and prevent you from getting any further problems with it. You may need to take this medication for several weeks before you see any improvement. It is also helpful in preventing heart attacks and strokes.
What happens if I miss a dose?
If you miss a dose of this medicine, take it as soon as possible. It is important to take this medicine at the same time each day and not later than 24 h after taking it. This will ensure that your blood pressure is at its lowest possible level. This will help to reduce your risk of heart problems and other health conditions. If you don’t take this medicine as directed, it may not work as well and your condition could get worse. This is especially true if you also take medicines for high blood pressure (antihypertensive drugs). This may lead to serious complications.[5]
Amlodipine and telmisartan side effects
Telmisartan and amlodipine are used to treat high blood pressure (hypertension). They help in reducing the high blood pressure level, so that the patient can have a better life. They also prevent the individual from having any cardiac issues such as strokes and heart attacks.
This medicine also helps in reducing swelling and fluid retention in the body. It works by reducing the level of sodium and potassium in the blood. It also relaxes the blood vessels, so that they can open properly and improve the flow of blood in the body.
Amlodipine is a calcium channel blocker that reduces the high blood pressure by expanding and relaxing the blood vessels. It also prevents the individual from having any type of cardiac issue such as cardiac arrest or strokes.
The medicine is also used to treat kidney problems in people. It also helps in reducing the amount of protein in the urine.
It is a combination of three medications; amlodipine, telmisartan, and hydrochlorothiazide. It is a drug that can be taken in tablet, capsule, syrup, cream, gel, ointment, or liquid form.[6]
Telmisartan and Amlodipine Uses
Taking these medicines can help lower blood pressure to prevent strokes, heart attacks and kidney problems. It also helps keep the arteries in your body healthy, so they can function properly.
Telmisartan is a medication used to treat high blood pressure (hypertension). It works by reducing the amount of work your heart and arteries have to do.
Before Using
The combination of telmisartan and amlodipine is a treatment for high blood pressure (hypertension). Hypertension is caused by a buildup of high levels of fluid in the arteries. When this occurs, it can damage the arteries, which can cause strokes and heart attacks, among other problems.
Telmisartan is an angiotensin receptor blocker (ARB) that acts on the angiotensin II receptors in the kidneys. It is also a calcium channel blocker (CCB). It can lower systolic and diastolic blood pressure (BP) by blocking angiotensin II. It is used to treat high BP and prevent heart disease, stroke, and kidney disease.[7]
Several clinical trials have shown that telmisartan combined with other antihypertensives like amlodipine or rosuvastatin is more effective than monotherapy in lowering BP. Moreover, this combination has many benefits such as renal protection, reduced inflammation, and lowered oxidative stress.
In the pooled analysis, telmisartan 40 or 80 mg plus amlodipine 5 or 10 mg significantly reduced the mean change in diastolic and systolic BP compared to telmisartan 40 or 80 monotherapy. It was also more effective in patients with diabetes and metabolic syndrome.
These results suggest that the telmisartan 40/amlodipine 2.5 combination may be more effective in controlling BP on a daily basis than telmisartan 80 monotherapy, particularly in patients with essential HTN who are not responding to telmisartan 40. This is because the telmisartan 40/amlodipine2.5 combination has longer-acting properties than telmisartan 80.
In addition, telmisartan/amlodipine has a good safety profile with a low incidence of adverse drug reactions (ADRs). Of the 15 ADRs in the telmisartan/amlodipine combination, only one patient had peripheral edema. The other ADRs were increased LDL cholesterol and hypotension. All ADRs were mild events and assessed as’recovering/resolving’ or’recovered/resolved’.[8]
Proper Use
When hypertensive patients are not able to achieve blood pressure (BP) targets with antihypertensive monotherapy, they may be switched to a combination of two medications with complementary modes of action. The most commonly prescribed combinations are telmisartan and amlodipine, which have shown promising results in several clinical studies.
The pharmacological activity of telmisartan is enhanced by the angiotensin II receptor antagonist [9,23]. In addition, a single oral dose of amlodipine reduces the risk of cardiovascular events and mortality. It also decreases systolic blood pressure by promoting diuretic action and increases sympathetic nerve activity.
Nevertheless, telmisartan and amlodipine should be used under the supervision of a physician. If used in high doses, these drugs can cause serious side effects.
This is especially true if amlodipine and telmisartan are administered together. This is because telmisartan degrades in the presence of basic excipients like sodium hydroxide or meglumine.
However, the toxicity of telmisartan can be minimized by using a lower dose of amlodipine and by increasing the number of telmisartan tablets taken. For this purpose, a bilayer tablet is recommended because it helps prevent the degradation of amlodipine.
In addition to this, it can help increase patient compliance with medication because the number of pills taken is reduced. This is important because a large number of pills can increase the chance that the patient will miss a dose.
The telmisartan and amlodipine combination has been demonstrated to reduce the risk of cardiovascular disease in patients with high blood pressure and dyslipidemia. The combination was tested in four randomized, double-blind, placebo-controlled trials.
These trials screened patients aged 19 years and older who had a sitSBP of 140 mm Hg or higher and a low-density lipoprotein cholesterol (LDL-C) level 250 mg/dL. After a 4-week washout/run-in period with therapeutic lifestyle changes, telmisartan (80 mg) was given once daily.
The use of telmisartan and amlodipine was found to be safe and well tolerated in these trials. It is therefore recommended that they are used to treat stage 1 or 2 hypertension.[9]
Precautions
Telmisartan and amlodipine are medications used to treat high blood pressure (hypertension). High blood pressure puts the heart and arteries under extra strain, increasing the risk of stroke, heart attack, and kidney problems.
Several studies have shown that telmisartan and amlodipine can be used in combination to improve treatment of hypertension. These combination therapies are more effective than using one of these drugs alone, and they also increase medication adherence.
In this study, the effects of fixed-dose combination therapy with telmisartan 40 mg and amlodipine 5 mg on 24-h antihypertensive efficacy in Japanese patients were evaluated. The results showed that telmisartan/amlodipine had greater 24-h BP reduction than control (control: 140+-13.4 mmHg, p0.001; telmisartan/amlodipine: 125+-8.9 mmHg, p0.001).
Combination telmisartan/amlodipine reduced the diastolic blood pressure (DBP) goal at the end of 8 weeks as well as the total blood pressure (TBP) goal. Compared with patients who received amlodipine monotherapy and then switched to telmisartan/amlodipine, those receiving telmisartan/amlodipine achieved the DBP goal at the end of 8 weeks more often.
The results of this study suggest that telmisartan and amlodipine may be useful for treating COVID-19, an inflammatory disease associated with a high risk for cardiovascular events such as strokes, heart attacks, and kidney failure. The combination is thought to work by inhibiting the action of the renin-angiotensin system.[10]
Those who are taking an ACE inhibitor, such as lisinopril, should not take telmisartan or amlodipine together. These medicines can decrease the effectiveness of lisinopril, leading to more severe side effects.
If a patient has diabetes, the use of telmisartan and amlodipine should be closely monitored. They can cause hypoglycemia in some people, which can lead to a dangerous drop in blood sugar levels.
In addition, telmisartan and amlodipine have been linked to the development of high blood sugar in certain people. This is not common, but it can cause serious problems if they are not taken properly.
This drug is not recommended for use during pregnancy because it can cause problems in the fetus. It is important to let your doctor know if you are pregnant or planning to become pregnant.
Side Effects
Telmisartan and amlodipine are used to treat high blood pressure (hypertension). They work by relaxing the blood vessels so that they don’t have to work as hard. They also help increase blood flow to the heart and other parts of the body.
Telmisartan is a member of the angiotensin receptor blocker (ARB) family, which includes drugs such as lisinopril (Zestril), enalapril (Vasotec), and nifedipine (Atenolol). It lowers blood pressure by blocking the activity of angiotensin II, a natural substance in the body that causes the vessels to narrow and increase blood pressure.[11]
It also increases the activity of renin, a hormone in the body that regulates blood pressure. It is a good choice for patients with low renin levels, especially those who are elderly or have diabetes or kidney disease.
The combination of telmisartan and amlodipine is an effective treatment for hypertension. It is also useful for preventing strokes and heart attacks in people with high blood pressure. It also helps to prevent kidney problems.
Combination therapy with telmisartan and amlodipine has been shown to have more BP-lowering effects than monotherapy with either drug alone, as well as being more convenient for patients. It is recommended as an initial therapy for patients likely to require more than one antihypertensive agent to achieve a desired BP goal.
In a large, controlled clinical trial, the combined use of telmisartan and amlodipine reduced systolic and diastolic blood pressure (BP) by more than a third in patients with mild to moderate hypertension whose BP was uncontrolled on 5 mg of amlodipine per day. The BP response was comparable with that in patients who received a single-pill telmisartan/amlodipine regimen (40 mg/5 mg or 80 mg/10 mg) and did not differ from that in placebo-treated subjects.
Another study found that telmisartan and amlodipine combined therapy was more effective than telmisartan and amlodipine alone at all doses, with mean 24-h BP reductions of -23.2/-14.6 mmHg for the highest-dose combination and -11.9/-6.9 mmHg for the lowest-dose combination compared with telmisartan and amlodipine monotherapy at all doses. Conclusion:[12]
