Zinc Acetate
Zinc Acetate Oral Solution USP. Zinc acetate oral solution usp is used to treat itchy skin conditions. The zinc acetate helps to reduce inflammation and redness, and it promotes drying of excess oil and fluids. It also works to protect the skin from irritants and allergens.
Other anti-itch agents may be included in the formulation.[1]
What should I avoid while taking zinc acetate?
Zinc is an essential trace element that plays a critical role in the maintenance of cellular integrity. It also promotes many enzymatic and transcriptional responses. In addition, zinc deficiency can lead to a variety of symptoms and diseases. These include anorexia, hepatitis C, type 1 diabetes, growth retardation, and skin disorders.
In patients who are receiving a bariatric surgery, vitamin or mineral supplementation is recommended to ensure adequate zinc intake. Failure to follow diet or vitamin management, postoperative complications such as vomiting or diarrhea, adverse follow-up care, and poor absorption may induce or aggravate a zinc deficiency.[2]
The oral solution of zinc acetate usp should be used with caution in pregnancy. Use is not recommended in the first trimester. In addition, zinc acetate should not be taken orally during breastfeeding.
This medication should not be used with products that contain magnesium, aluminum, calcium, iron, or other minerals. These can interfere with the absorption of zinc acetate into the bloodstream and reduce its effectiveness.
Zinc acetate tablets should be taken on an empty stomach at least 1 hour before or 2 to 3 hours after meals and at least 1 hour separated from beverages other than water. If you take zinc acetate with food or alcohol, you should consume a small amount of water to help avoid gastrointestinal irritation.
Taking too much zinc can cause nausea, vomiting, loss of appetite, stomach cramps, and diarrhea. If you have any of these symptoms, you should stop taking zinc and seek medical attention right away. This is especially important if you are also taking any other supplements, medications, or natural remedies that may affect your body’s ability to absorb or use zinc effectively.[3]
Zinc acetate side effects
Zinc is a mineral that is essential to the health of humans. It is involved in many vital functions, including the formation of nucleic acid-binding proteins and cell growth and development. It also acts as an anti-oxidant, which helps to protect the body from harmful free radicals and toxins.
It also enhances DNA repair, boosts the immune system, and accelerates apoptosis in malignant cells. This is why zinc oxide has been used to prevent actinic keratosis (AK). In addition, it also has anti-inflammatory properties that help reduce skin symptoms such as itching, redness, and pain.[4]
However, it can cause side effects if taken in high doses or for a long time. Some of the most common side effects include nausea, diarrhea, vomiting, and stomach pain. If you experience any of these side effects, stop taking zinc acetate and talk to your doctor.
This medicine may also cause serious side effects if you take it with other drugs. It is important to tell your doctor about all the drugs you are taking, including prescription and over-the-counter medicines, vitamins, and supplements. You should also avoid taking it if you have an allergy to zinc.
You should also tell your doctor if you have any medical conditions, such as kidney disease, diabetes, or heart problems. These conditions may make it harder for your body to absorb the drug. You should also tell your doctor if you are pregnant or breastfeeding.[5]
Several studies have shown that zinc can improve the symptoms of inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. It also helps to treat irritable bowel syndrome and gastritis. It is also an effective treatment for chronic constipation and bloating.
Zinc acetate dosing information
The proper dosage of zinc acetate is important to achieve the desired results. The recommended starting dose is 75 mg of elemental zinc per day in 2 or 3 divided doses. The maximum dose should not exceed 150 mg per day. This will provide adequate amounts of copper without causing excess side effects.[6]
For the most part, zinc acetate should be taken on an empty stomach. This is especially true if you have food allergies or gastrointestinal (GI) problems such as constipation. The best time to take this medication is at bedtime.
Zinc acetate is not for the faint of heart, and should only be used under the supervision of your doctor. If you are pregnant or planning to become pregnant, this medication should be avoided all together.
This is the best way to avoid any potential interactions with this drug. It may also help you get the most from your treatment. The most common potential interactions are with drugs that contain magnesium, aluminum, calcium, iron and/or other minerals. Some of these can interfere with the absorption of zinc acetate and may even be the reason why you did not get the full benefits from this product. To minimize these possible side effects, follow all of your medication instructions exactly as directed.[7]
What other drugs will affect zinc acetate?
Zinc is an essential trace element that plays a role in several important physiological processes in the body. Its functions include antioxidant activity, DNA repair, and skin integrity maintenance.
It also helps the immune system fight disease-causing cells. Many medicines are made with zinc, including some antiviral drugs and some antibiotics.[8]
In addition, it is a necessary component of certain proteins and enzymes. Some diseases and conditions may be caused by a deficiency in zinc, including type 1 diabetes, autoimmune disorders, growth retardation, taste disturbances, and gastrointestinal problems.
Some medicines can affect the absorption of zinc acetate, so it is important to take it on an empty stomach unless otherwise directed by your doctor. You should also avoid foods and beverages that can interfere with your body’s ability to absorb zinc, such as bread, bran, hard-boiled eggs, coffee, and milk.
Your doctor may want to change the dose of your medicine if you are taking other drugs that can affect the absorption of zinc acetate, such as levoFLOXacin (levothyroxine sodium), Suprep Bowel Prep, or any other products containing magnesium, aluminum, calcium, iron, or other minerals.
Other drugs that can affect the absorption of zinc are diphenylhydramine and pramoxine. These medications may affect the way your body metabolizes zinc acetate, which can cause serious side effects or decrease its effectiveness.[9]
Another drug that can affect the absorption of zinc is polaprezinc, a medication used to treat erosive pustular dermatosis (EPD). The medication is a combination of a zinc complex and a synthetic corticosteroid that is applied topically to the affected areas. It is effective in reducing the inflammatory and atrophic symptoms of EPD, which often occur on the scalp or legs.
What is zinc acetate?
Zinc acetate is used for the prevention and treatment of cold symptoms. It works by boosting immunity, helping your body fight off infections and reducing the duration of flu symptoms. It is also used for certain types of cancer and high blood pressure.[10]
It can be taken by mouth in the form of an oral solution usp or a lozenge. It is also available in a spray that you can use sublingually, which allows you to bypass the digestive system and get zinc directly into the bloodstream. This method is safer than taking a pill because it does not cause gastrointestinal side effects.
To evaluate the efficacy of a formulation containing zinc acetate dihydrate, we used a mouse model of herpes simplex virus 2 (HSV-2). Formulations containing 0.3 to 1% zinc acetate dihydrate were able to prevent 75 to 85% of mice from becoming infected by a viral challenge with 106 PFU per mouse.[11]
We then conducted extended optimization and stability studies to further determine the safety, pharmacokinetics, and efficacy of a 0.5% zinc acetate dihydrate gel. This formulation remained stable for 6 months at 30degC and 5 months at 40degC. The methyl paraben content, osmolality, and pH of the formulations did not change significantly over time. However, gel viscosity did decrease significantly for some formulations.[12]
Before taking this medicine
Zinc acetate is sprayed into the sublingual and buccal mucosa, a safe, convenient and effective way to deliver zinc for its health benefits. It is absorbed via serum albumin, bypassing the digestive tract and directly into systemic blood circulation. This approach overcomes problems such as aging, reduced absorption due to poor eating habits, interactions with foods and drugs as well as gastrointestinal side effects like indigestion or nausea.
The spray reaches the brain and the nasal cavity, where it is rapidly absorbed and metabolised by the body to produce its health benefits. It is a high-powered, low-volume, non-irritating aerosol spray with a pleasantly minty flavour that contains the active ingredient zinc acetate, as well as a number of other vitamins and minerals.[13]
The spray is accompanied by a slick, glossy packaging that allows it to be easily stored and transported. It also carries a GMP (Good Manufacturing Practice) certification, which is vital for a successful product launch and for the quality of the finished medicine. It uses AIRLESS vial technology, which keeps the spray fresh for the duration of each bottle. Its patented nozzle design allows for a single spray to release thousands of microdroplets with a molecular weight of over a million.[14]
How should I take zinc acetate?
NordAid’s Sublingual Zinc Spray is a novel, easy-to-use, and fast-acting nutritional supplement that utilizes microdroplets of the active substance to deliver Zinc and Vitamin B5 safely and directly into the systemic blood circulation.
This innovative approach overcomes several common issues associated with the low absorption of Zinc due to aging, gastrointestinal diseases and co-administration with other drugs and food. It is also useful in cases where it is not possible to obtain a sufficient amount of Zinc from the food intake and in those who wish to boost their immunity.[15]
To assess the stability of zinc acetate formulations, we performed stability studies by testing methyl paraben content, osmolality, and pH of the gels at different time points (0.5, 2, 4, 6, 9, 12, and 24 hours). All gels were stable over a 6 month period at 30degC; however, some gels (such as those containing sodium citrate) had significantly decreased viscosity.
Using an HSV-2 challenge model, we evaluated the effectiveness of three prototype formulations (formulations D, E, and G) formulated in carrageenan to protect mice against a high-dose vaginal challenge of 106 PFU per mouse.
Compared to vehicle-only gel, the formulations containing 0.3 to 1% of zinc acetate dihydrate (ZnAED) protected 75 to 85% of the mice against viral infection. Furthermore, they met or exceeded criteria for physicochemical properties, prediction of vaginal coating, in vitro release of the zinc, and effects on cell viability and cell monolayer integrity.[16]
What happens if I miss a dose?
If you do not take zinc acetate as prescribed, it may not be enough to protect you from infection. It is very important to remember that only 20% of the zinc acetate is released from the oral solution into your body. This means that you must use other forms of protection to get the full benefit from this medicine, such as vaginal lubricants, condoms, and topical creams.
Fortunately, a new formulation of zinc acetate in carrageenan gel (formulations D, E, and G) has been shown to provide 70% protection against HSV-2 in the laboratory mouse model when applied daily for 2 weeks or every other day for 4 weeks prior to virus challenge. These results are significant, and they suggest that zinc acetate in carrageenan is an effective, low-cost method for protecting women from vaginal infections.[17]
